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This guidance statement provides return-to-work guidance for both employers and OEM physicians who support businesses in implementing safe return-to-work strategies. It provides guidance on workplace respirator and facial covering use decision-making and summarizes special considerations for different industries (eg, health care, food, general office/warehouse, retail, transportation/travel, construction, maritime/offshore, and energy/utilities). The role of safety and industrial hygiene in ensuring safe workplaces through the hierarchy of controls (hazard elimination, substitution, engineering, administration, and personal protective equipment) is highlighted. Lastly, guidance is provided on legal and human resources considerations including workers’ compensation and the importance of connecting employees to mental health resources.