Workers are uniquely susceptible to the health hazards imposed by environmental changes. Occupational and environmental medicine (OEM) providers are at the forefront of emerging health issues pertaining to working populations including climate change, and must be prepared to recognize, respond to, and mitigate climate change-related health effects in workers. This guidance statement focuses on North American workers' health effects that may occur as a result of climate change and describes the responsibilities of the OEM provider in responding to these health challenges.