Safety and productivity in the workplace are intimately related to worker health. Well-rested, alert employees are critical to safe and productive operations. Virtually everyone experiences some level of fatigue from time to time. However, excessive fatigue while working is an important condition in which the interrelationship of health, safety, and productivity can create a vicious or a virtuous cycle. Specific medical and lifestyle interventions have been shown to promote a well-rested and alert workforce. Because of the potential impact of fatigue on health, safety, and productivity, any organization in which individuals work extended hours or hours during which people typically sleep can benefit from addressing fatigue in the workplace.