Many businesses struggle to re-open during COVID-19. This pandemic has resulted in an increased awareness of employee health as a core strategy in organizations. And, the when and how businesses can reopen will depend on a variety of factors including federal, state, or local policies. Guidance regarding return-to-work decision-making from a worker-safety and medical perspective incorporating the principles of risk, capacity, and tolerance is critical. This document is intended to provide return-to-work guidance for both employers and the OEM physicians who will be supporting businesses to implement safe return-to-work strategies.